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Hepatic Impairment: In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in increases in AUC (85%) and Cmax (47%) compared to age-matched volunteers with no hepatic impairment. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. The medication was first developed in England for used as an blood pressure reducer, but it worked better for penile dysfunction, so the makers decided to market it for that. Such an event may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including possible permanent loss of vision, that has been reported rarely post-marketing in temporal association with the use of all PDE5 inhibitors.

A: Viagra (sildenafil) must be used with caution in patients taking an antihypertensive medication. Feenstra J, vanDriePierik RJHM, Lacle CF, Stricker BHC "Acute myocardial infarction associated with sildenafil." Lancet 352 (1998): 957-8 16. The study was supported by an independent grant from Pfizer, which makes Viagra.

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Lori Poulin, PharmD Q: Can stroke survivors take Viagra? Women writing to Dear Abby, for example, were either no longer interested in sex (and thus Viagra created new unwelcome pressure to be sexually active again), or fearing their husbands were having affairs in the context of their newfound sexual potency, and/or experiencing sometimes painful physiological effects of reigniting their sex lives later in life.

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Only men aged 18 years and older with erectile dysfunction are suitable candidates for VIAGRA connect. McMahon CG, Smali R, Johnson H "Efficacy, safety and patient acceptance of sildenafil citrate as treatment for erectile dysfunction." J Urol 164 (2000): 1192-6 29.

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Measurements of heart function were made before and after each injection.  This included blood pressure readings, electrocardiograms and echocardiograms, as well as blood samples to confirm relatively equal levels of sildenafil and other enzymes.  Results showed that each dobutamine injection stimulated heart function, increasing heart rate and the force of each heartbeat used to pump blood throughout the body.  “This stimulation is similar to the way the nervous system normally increases heart function when triggered by emotional or exercise stress, or in diseases such as heart failure,” adds Kass. Although plasma levels of sildenafil at 24 hours post dose are much lower than at peak concentration, it is unknown whether nitrates can be safely co-administered at this time point [see CONTRAINDICATIONS]. Men and women are wonderfully complex and diverse creatures when it comes to sexuality AND in general. A: When taking more than one medication, it is important to make sure there are no drug interactions. The usual recommended dose of Viagra is 50 mg administered as needed approximately one hour prior to sexual activity. I tried 150 mg two different times and that produced the desired effect. The link between vision loss and Viagra is as yet unknown. Maximum dosage: 20 mg, taken three times per day about 4 to 6 hours apart. This can cause your body to process drugs more slowly. This information is not a substitute for medical advice.