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Gharbia, PharmD Q: What's the problem with taking Viagra occasionally two times in the same day, maybe 12 or so hours apart? I would like to know if Viagra would be all right to take with them. However, in vitro studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside (a nitric oxide donor). Read More what are the chances of me getting my wife pregnant. we do have children but that was before i was diagnosed and before all the meds. Increased side effects can include blood pressure that’s too low. A: Viagra (sildenafil) works by inhibiting the chemical phosphodiesterase, which leads to an increase in the effect of nitric oxide.

VIAGRA is formulated as blue, film-coated rounded-diamond-shaped tablets equivalent to 25 mg, 50 mg and 100 mg of sildenafil for oral administration. Most pharmaceutical companies then charge a lot of money for the drugs to make up for these costs. While the precise biological actions of sildenafil in the heart are not fully understood, the drug is known to work by stopping the action of an enzyme, called phosphodiesterase 5 (PDE5A), the researcher says.  This enzyme is involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit overgrowth in the heart.  PDE5A is also the biological pathway blocked in the penis by sildenafil to promote the relaxation of blood vessels and maintain erections.  Funding for this study was provided by the National Institutes of Health (NIH), the Peter Belfer Laboratory Foundation and the Bernard Family Foundation.  The makers of the drug had no involvement in the design or support of the research.

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Viagra overdose A Viagra overdose can be serious. 5 mmHg when sildenafil was co-administered with alcohol versus -17. Viagra/Revatio may also be used for purposes not listed in this medication guide. One of the possible effects Viagra can have is to lower blood pressure. If you are over 65 years old, you may find that the medication stays in your body for longer. Reduced testosterone levels combined with higher levels of estrogen may feminize your body.

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Tell your doctor if you are pregnant or plan to become pregnant. In placebo-controlled clinical studies, the discontinuation rate due to adverse reactions for VIAGRA (2. If you have an erection that lasts more than 4 hours, get medical help right away. This is essentially a different type of Viagra which is used for a different FDA approved indication.

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The effects that the “average” man may experience are often mild. Whether or not Viagra is safe for you will depend on the reason for your heart valve replacement. Also of note is that currently sildenafil has only two Food and Drug-labeled indications and that is for erectile dysfunction or treatment of pulmonary arterial hypertension. Pharmaceutical companies must pay for years of clinical trials before a drug can be deemed safe by the FDA to be on the market. 5, 3, 4, 6 and 8 hours after VIAGRA or matching placebo. Whilst alcohol can help to overcome anxiety, it can also affect sexual prowess. Therefore the medication should be used with caution by patients who have left ventricular outflow obstruction and should only be used by patients who are hemodynamically stable prior to starting therapy. Examples of these drugs include: Nitrates, such as isosorbide mononitrate, isosorbide dinitrate, or nitroglycerin. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. Living in the pharmaceutical era it sometimes seems easiest and most expedient to turn to medication to enhance our lives or fix our problems. A glass of wine or a single beer is usually fine, but could still have some effect. I have had years of this pain and headaches before something was done. These side effects included:   Respiratory tract infections Back pain Flu-like symptoms Joint pain.Q: Is there a less expensive substitute for Viagra? Also we know that one of the main sx.of liver disease left untreated can be a devastating one all on its own. What angers me is that it shouldn't be us arguing over these issues, the drug companies should be finding out. Similar to Levitra, the recommended starting dose for Cialis, as needed, is 10 mg.